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ContraVir Pharmaceuticals Inc. (NASDAQ: CTRV) is watching its shares climb on Thursday after the company reported positive interim data from its ongoing Hepatitis B (HBV) mid-stage trial. Specifically, the company announced data for CMX157, its highly potent prodrug of tenofovir.

Overall the study is the first evaluation of CMX157 in HBV patients, and directly compares CMX157 to tenofovir disoproxil fumarate (TDF, Gilead’s Viread) in chronically infected HBV patients.

The CMX157 treated patients showed an average 99% reduction in HBV viral load compared to baseline. What was significant here was that the observed antiviral activity for CMX157 is comparable to that observed in TDF-treated patients, but at less than 10% of the dose.


A key goal of this study was to monitor levels of active tenofovir in the blood, exposure to which is a key predictor of off-target side effects. Following oral dosing, levels of CMX157 and active tenofovir in the bloodstream are roughly dose proportional and similar both in chronic HBV patients as well as in an earlier healthy volunteer study. Notably, CMX157 does not appear to break down readily into active tenofovir in the blood in contrast to patients taking Viread.

share stock: Beasley Broadcast Group Inc.(BBGI)


Advisors’ Opinion:

  • [By Lisa Levin]

    Tuesday afternoon, the cyclical consumer goods & services sector proved to be a source of strength for the market. Leading the sector was strength from Beasley Broadcast Group Inc (NASDAQ: BBGI) and Lee Enterprises, Incorporated (NYSE: LEE).

  • [By Benzinga News Desk]

    Beasley Broadcast Group (NASDAQ: BBGI) and Greater Media have entered into a definitive agreement under which Beasley will acquire all of the outstanding stock of Greater Media for approximately $240 million.

share stock: LeMaitre Vascular, Inc.(LMAT)


Advisors’ Opinion:

  • [By Monica Gerson]

    The list of below stocks is notable as the shares have traded on sequentially increasing volume spanning the trading days from September 16 to September 20:

  • [By Lisa Levin]

    In trading on Thursday, healthcare shares rose by just 0.6 percent. Meanwhile, top losers in the sector included LeMaitre Vascular Inc (NASDAQ: LMAT), down 5 percent, and pSivida Corp. (NASDAQ: PSDV), down 3 percent.

share stock: Valhi Inc.(VHI)


Advisors’ Opinion:

  • [By Lisa Levin]

    In trading on Thursday, basic materials shares slipped by 0.61 percent. Meanwhile, top losers in the sector included Valhi, Inc. (NYSE: VHI), down 13 percent, and LSB Industries, Inc. (NYSE: LXU), down 7 percent.

share stock: Natural Grocers by Vitamin Cottage, Inc.(NGVC)

Advisors’ Opinion:

  • [By Peter Graham]

    A long term performance chart for Whole Foods Market shows along with mid cap peerSprouts Farmers Market Inc (NASDAQ: SFM) and Natural Grocers by Vitamin Cottage (NYSE: NGVC) appearing to all be in downtrends that may or may not have leveled off:

  • [By Peter Graham]

    A long term performance chart for Whole Foods Market shows along with mid cap peerSprouts Farmers Market Inc (NASDAQ: SFM) and Natural Grocers by Vitamin Cottage (NYSE: NGVC) largely drifting lower with two price spikes:

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